Endocrine Abstracts

In light of the gender differences in bone geometry, sex steroids have been proposed as key regulators of pubertal periosteal bone formation. Sex steroids may affect periosteal bone apposition following activation of sex steroid receptors [androgen receptor (AR), estrogen receptor alpha (ERα) or beta (ERβ)]. Traditionally, it has been assumed that AR-mediated androgen action stimulates periosteal bone formation and thereby determines the larger bone size in males, wh...